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研究

公开研究方法，支持评测与复现

闭环研发平台建立在经过同行评审的研究方法之上，相关文献均附原始出处。

已发表的研究方法

  1. AsEP：抗体特异性表位预测

    采用基于图的深度学习方法，并与已发表的基线方法进行基准比较（ICML 2024 Workshop）。

    阅读论文 →

  2. CDR 环构象分析

    通过结构生物信息学方法，分析抗体与抗原结合时 CDR 环的构象变化（mAbs 2024）。

    阅读论文 →

  3. 知识库检索

    以经过整理的复合物数据库支持平台检索。

    了解详情 →

学术论文

Nature Biotechnology · arXiv · NeurIPS 2024 · mAbs按时间倒序 · 每条均链接至原始出处

  1. 2026

    A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability

    Erasmus, M. F., Bedinger, D., Hopkins, E., … Denzler, L., Liu, C., … Bradbury, A. R. M. (2026).

    Nature Biotechnology

    AIntibody · Benchmark · Antibody Design

    阅读论文 →
  1. 2025

    AbRank: A Benchmark Dataset and Metric-Learning Framework for Antibody-Antigen Affinity Ranking

    Liu, C., Pelissier, A., Shao, Y., Denzler, L., Martin, A. C. R., Paige, B., & Rodríguez Martínez, M. (2025).

    预印本arXiv

    Benchmark · Affinity Ranking

    阅读论文 →
  1. 2024

    AsEP: Benchmarking Deep Learning Methods for Antibody-specific Epitope Prediction.

    Liu, C., Denzler, L., Chen, Y., Martin, A., & Paige, B. (2024).

    Advances in Neural Information Processing Systems 37 (NeurIPS 2024) — Datasets and Benchmarks Track

    Deep Learning · AsEP · Benchmark

    阅读论文 →

  2. Do antibody CDR loops change conformation upon binding?

    Liu, C., Denzler, L. M., Hood, O.E.C., & Martin, A. C. R. (2024).

    mAbs

    Antibody · CDR · mAbs

    阅读论文 →

学术会议

  1. 2025

    abYcloud — from research to startup

    Presented by Chunan L., University College London · Research Amplified: Harnessing AWS to Power Scientific Innovation — London, UK

    Talk · AWS

    查看海报 →
  1. 2024

    C-169: Advancing Antibody-Specific Epitope Prediction with a Graph-Based Approach

    Liu, C. et al. · Intelligent Systems for Molecular Biology (ISMB) 2024 — Montreal, Canada

    Graph · Epitope Prediction

    查看海报 →

  2. AsEP: Benchmarking Deep Learning Methods for Antibody-specific Epitope Prediction

    Liu, C. et al. · ICML 2024 Workshop — AI for Science — Vienna, Austria

    ICML · Workshop

    查看海报 →
  1. 2023

    B109: Antigen-Specific Antibody Design: Preliminary Progress

    Presented by ChuNan L., University College London · Protein & Antibody Engineering Summit (PEGs) 2023 — Lisbon, Portugal

    Antigen-Specific · PEGs

    查看海报 →

开放资源与数据集

开放数据

AsEP 基准数据集

经过整理的抗体与抗原复合物数据，用于评估表位预测方法的性能。

下载 →

github · biochunan/AsEP-dataset

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